Guanosine triphosphate

  • 9- β -D - Ribofuranosylguanin -5'-triphosphate
  • 9- β -D - ribofuranosyl -2-amino -6-oxo -purin- 5'-triphosphate

Fixed

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Guanosine triphosphate (GTP) is an energy-rich chemical compound from the group of nucleoside triphosphates. It serves, in particular for energy storage in anabolic ( building) processes of cellular metabolism, such as a product of the citric acid cycle (transfer of energy from carbohydrates and fats to GTP, which is formed by addition of a phosphate group to GDP) or protein biosynthesis. In addition, GTP has a central role in the transmission of signals in the cell ( signal transduction) as a substrate of G- proteins.

GTP molecule is a condensation product of the purine base guanine, the sugar ribose and three molecules of phosphate. By elimination of a phosphate group to form guanosine energy is released. By means of the guanylyl cyclase enzyme can be synthesized from GTP, the signal molecule cGMP. GTP is also used when nukleozytosolischen transport in the form of Ran - GTP.

Ran -GTP

Ran -GTP ( " Ran " by Ras -related nuclear protein) is an important factor for mass transfer cytoplasm - nucleus. Depending on the direction of transport (export or import of molecules ) or exportin importin first be required as a carrier. The two modes have the following in common: Ran -GTP provides the energy necessary to bring exportin molecule with or without importin molecule into the cytoplasm from the nucleus. Ran -GTP is converted to Ran -GDP in the cytoplasm. Ran -GDP diffuse back into the nucleus. By RanGEF Ran -GDP is converted to Ran -GTP, which can attach to an exportin / importin again.

CAS registry number Condensation reaction Guanosine diphosphate Cyclic guanosine monophosphate Adenosine triphosphate Cytidine triphosphate Uridine triphosphate
284472
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