HABP2

• OMIM: 603 924
• UniProt: Q14520
• MGI: 1196378

The factor VII - activating protease ( FSAP Hyluronan -binding protein 2) is a serine protease that was discovered only recently. FSAP ( engl. factor VII -activating protease ) has two important functions in the system of hemostasis. For one, it activates factor VII to factor VIIa and thus starts the plasmatic coagulation of the blood. On the other hand, it is also an activator for certain plasminogen activators especially for prourokinase, a precursor of urokinase. The enzyme plasmin is at the end of the activation string and is able to dissolve a fibrin clot again. A defect in the gene encoding the FSAP is known as the Marburg I polymorphism (English ). This defect could theoretically lead to an inadequate activation of plasminogen activators, which in turn could result in an increased tendency to thrombotic events. This theory was, for example, by Hoppe et al. demonstrated in a study. Van Minkelen et al. However, in a separate study found no association between the Marburg I polymorphism and thrombotic events. They introduced the results of Hoppe back to their selection criteria for study participants in the groups of patients and control subjects.

Representation of the activation

FSAP                  ↓             u -PA per ← u -PA              ↓ Plasminogen plasmin →                   ↓            Fibrin, fibrin degradation products → literature

• Roman J.: Factor VII activating protease ( FSAP): a novel protease in hemostasis. Biol Chem 2002; 383: 1119-1124.
• Roman J, Vermöhlen S, Feussner A, Stohr H. The FVII activating protease cleaves single-chain plasminogen activators. Haemostasis. 1999, 29 ( 5) :292 - 299th