Hans D. Ochs
Hans Dieter Ochs, Hans Dieter Ochs, ( born September 29, 1936 in Spaichingen ) is an immunologist and pediatrician. He is a professor in the Department of Pediatrics, Division of Immunology, Infectious Diseases and Rheumatology, University of Washington School of Medicine, Seattle.
Life and research
Hans D. Ochs graduated from the Albert -Ludwigs- University of Freiburg and was a postgraduate at the Kapiolani Medical Center for Women & Children, Honolulu and the University of Tübingen. In Tübingen, he became in 1956 a member of the Catholic Student Association AV Guestfalia Tübingen in the CV. It is approved by the German Society for Pediatric and Adolescent Medicine and the American Board of Pediatrics and the American Board of Allergy and Immunology.
Hans D. Ochs explores the molecular basis of primary immunodeficiency diseases with special interest in genes that are associated with Wiskott -Aldrich syndrome, hyper- IgM syndrome, X -linked agammaglobulinemia, IPEX syndrome and autosomal dominant hyper-IgE syndrome. In order to improve the long -term consequences of these diseases, he has actively participated in clinical trials in order to develop strategies to Immunoglobulinersatztherapie, hematopoietic stem cell transplantation and gene therapy.
Ochs 's clinical interest focuses on the use of intravenous and subcutaneous immunoglobulin in patients with antibody weaknesses and the in-vivo analysis of antibody production by bacteriophage Phi X 174 He and his staff also contributed to the identification of several genes responsible for on are the X chromosome localized Primary immunodeficiency diseases are responsible, including CD40L, Wiskott -Aldrich syndrome protein tyrosine kinase buttons and FOXP3.
Lately, he has focused on the gene uracil - DNA glycosylase, which causes a rare form of autosomal recessive hyper - IgM syndrome and STAT3, which, when mutated, which draws autosomal dominant hyper-IgE syndrome by itself.
In 1995 he moved to the hospital for immunodeficiency diseases at the University of Washington for Seattle Children 's Hospital in order to provide diagnostic evaluations and clinical treatments for both children and adult patients with primary immunodeficiency diseases. He initiated and also maintains a successful collaboration with the Center for Bone Marrow Transplantation of the Fred Hutchinson Cancer Research Center since the early 70s and participated in the creation of transplantation protocols for patients with SCID, Wiskott -Aldrich syndrome, Chronic Granulomatous Disease ( septic granulomatosis ) and Hyper- IgM syndrome in part.
The ox / Torgerson laboratory at Seattle Children's Hospital konzenteriert to:
- Autoimmunity and immune dysregulation
- Regulatory T cells and mutations of FOXP3
- Molecular consequences of heterozygous dominant-negative STAT3 mutations and their relationship to autosomal dominant hyper-IgE syndrome
Memberships and offices
- American Association of Immunology
- American Federation for Clinical Research
- Society for Pediatric Research
- American Pediatric Society
- Clinical Immunology Society
- European Society of Immune Deficiencies
He serves on the committees of the Immune Deficiency Foundation, the Jeffrey Modell Foundation, U.S. Immunodeficiency Network ( USIDNET ) and International Union of Immunological Societies ( IUIs ). Hans D. Ochs is also a founding member of the USIDNET / Clinical Immunology Society ( CIS) Annual Summer School and the Editorial Board of the Tohoku Journal of Experimental Medicine and Türkish Journal of Medical Sciences.
Publications
- ER Stiehm and Jerry A. Winklestein: Immunologic Disorders in Infants and Children. 5th edition. Saunders, 2004, ISBN 0-7216-8964-7.
- With C. I. Edvard Smith and Jennifer M. Puck: Primary Immunodeficiency Diseases: A Molecular & Genetic Approach. 2nd edition. Oxford University Press, 2006, ISBN 0 - 19-514774 -X.
More than 400 publications, including as co -author in: Blood (Journal of the American Society of Hematology ), Journal of Immunology, European Journal of Immunology, Journal of Pediatrics, Cell Growth & Differentiation, Nature Genetics, Nature Reviews Immunology, Nature Medicine, Journal of Clinical Investigation, Journal of Experimental Medicine, The New England Journal of Medicine, The Lancet, Immunity, Journal of Biological Chemistry, Experimental Haematology, Bone Marrow Transplantation and the Journal of Allergy and Clinical Immunology.