Hematoporphyrin

  • Hematoporphyrin IX
  • 7,12- bis (1- hydroxyethyl) - 2,8,13,17 -tetramethyl- 21H, 23H - porphine - 2,18 - dipropionic acid

Violet powder

Fixed

172-173 ° C

307 mg · kg -1 ( LD50, mouse, i.v.)

Template: Infobox chemical / molecular formula search available

Hematoporphyrin, also Haematoporphyrin, (English: hematoporphyrin ) is created by the acidic hydrolysis of the hemoglobin. Here, the protein chains to be cleaved, and the iron ( II) ion removed. Moreover, the two vinyl groups are hydrated, hematoporphyrin is thus an iron-free heme.

Properties

Hematoporphyrin differs from protoporphyrin IX, characterized in that the two vinyl groups have been transferred as a result of addition of water in the hydroxyethyl radicals. Since the reaction does not take place stereospecifically, there hematoporphyrin of 4 stereoisomers.

Use

  • Detection of blood in the stool ( hematoporphyrin test, guaiac test)
  • Photosensibilierung of tumors ( Photodynamic Therapy - PDT)
  • Antidepressant since the 1920s
CAS registry number PubChem Hydration reaction Stool guaiac test
369339
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