Hemoglobin, alpha 1

• OMIM: 141800
• UniProt: P69905

α -globin ( HBA1, HBA2, hemoglobin, α - subunit ) is a protein that is part of the hemoglobin protein complex in vertebrates.

Function

The human hemoglobin - α1 gene cluster is located on chromosome 16, comprising 30 kilobases and seven loci: 5'- ζ - pseudo- ζ - μ - pseudo- α -1 - α 2 - α 1 - θ - 3 '. The coding sequences for α -2 ( HBA2 ) and α -1 ( HBA1 ) are identical. These genes differ only slightly in the 5 ' untranslated region and introns, but they differ significantly in the 3' untranslated region. Two α chains, two β chains form plus the hemoglobin A ( HbA ), which in the normal adult life comprises about 97% of the total hemoglobin; α - chains in combination with delta chains constitute HbA - 2, which ( "fetal hemoglobin " ) accounts for HbF with the remaining 3 % of the hemoglobin in adults. α -thalassemia resulting from the deletion of the α genes as well as by deletion of both HBA2 and HBA1; of some α - thalassemia without deletion have been reported.

Interaction

α -globin to β -globin includes protein-protein interaction.