Histamine receptor

Histamine receptors are G- protein coupled receptors, of which the neurotransmitters, and the tissue hormone histamine mediates its functions. The family of the histamine receptors include the receptors H1, ​​H2, H3 and H4. The H1, H2 and H4 receptors are particularly responsible for the effects of histamine in the context of defense reactions, such as mast cell activation, release of interleukins, recruitment of leukocytes, flushing, stomach acid release, vomiting and expansion and increase in the permeability of small blood vessels associated with hives. H3 receptor mediated, in addition to the H1 receptor, neurotransmitter functions of histamine. These include, for example, the regulation of the release of histamine ( autoregulation ), acetylcholine, norepinephrine and serotonin and the regulation of circadian rhythms.

  • G protein- coupled receptor
  • Protein group
Loratadine Cetirizine Fexofenadine Doxylamine Famotidine Roxatidine
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