Idarubicin

  • (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacendion
  • 4- Demethoxidaunorubicin
  • 58957-92-9
  • 57852-57-0 (hydrochloride)

L01DB06

Fixed

Hydrochloride

Risk

Hydrochloride

Template: Infobox chemical / molecular formula search available

Idarubicin and 4- Demethoxidaunorubicin, is a substance belonging to the anthracyclines.

Use

It is used as a cytostatic agent in the context of combination chemotherapy used by acute leukemia.

Idarubicin is a DNA intercalator. The lack of methoxy group compared with daunorubicin improved the lipid solubility and thus the uptake into the cell, where it then comes to growth inhibitory interaction with topoisomerase II.

Swell

  • Franz von Bruchhausen, Eberhard Hack Thal, Siegfried Ebel: Hagers handbook of pharmaceutical practice. Springer DE, 1999, ISBN 354062644-1, p 667 ( limited preview on Google Book Search ).
  • Margaret Barton Burke, Gail M. Wilkes, Karen Ingwersen: Cancer Chemotherapy Care Plans Handbook. Jones & Bartlett Learning, 2002, ISBN 076 371 481 X, pp. 306 ( limited preview on Google Book Search ).
CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Intercalation (chemistry) Type II topoisomerase
407105
de