Idoxuridine

  • 2'-deoxy -5-iodo -uridine
  • 1 - [( 2R, 4S, 5R )-4- hydroxy-5 -hydroxymethyl- oxolane -2-yl ] - 5 -iodo- pyrimidine-2 ,4 -dione ( IUPAC)

D06BB01, J05AB02, S01AD01

White powder

193-194 ° C

Poorly in water ( 1.6 g · l-1 at 20 ° C)

Attention

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Idoxuridine (2' -deoxy -5-iodo -uridine ) is a nucleoside analogue of the biochemical uridine. It consists of 5 - iodouridine and deoxyribose.

It is used as an antiviral agent (eg Virunguent ®) against herpes viruses. According to Coster et al. it should have a similar efficacy to acyclovir. Idoxurin acts as an antagonist of thymidine in the DNA synthesis of virus.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Structural analog Aciclovir Receptor antagonist
407406
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