Imidazoline receptor

Imidazoline receptors are receptors in the brain suspected in which clonidine and other imidazoline derivatives (such as tolazoline, guanfacine, moxonidine, rilmenidine and Tolonidin ) act as agonists. Thus, a antihypertensive effect (via the I1 receptor, see below).

There are three classes of imidazoline receptors:

  • I1 mediated sympatholytic effects that lead to a reduction in blood pressure.
  • I2 is an important allosteric binding site for the monoamine oxidase.
  • I3 regulates the insulin secretion from the beta cells of the pancreas.

As an endogenous agonist agmatine has been found, which also binds to α2 -adrenoceptors other than at I1 and I2 receptors.

Swell

  • Hermann Rompp ( Lim. ), Jürgen Falbe and Manfred Regitz (ed.): Encyclopedia of chemistry Rompp. 10th edition, Thieme, Stuttgart 1996/99, ISBN 3-13-107840-5, pp. 1883 ( 1 CD -ROM).
  • Geoffrey A. Head, Dmitry N. Mayorov: Imidazoline receptors, novel agents and therapeutic potential. In: Cardiovascular and Hematological Agents in Medicinal Chemistry 4 (1 ) (2006 ), pp. 17-32. PMID 16529547
  • WHO ATC / DDD Index: Imidazoline receptor agonists
  • Receptor
Endogeny
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