Interleukin 8 receptor, beta

• OMIM: 146 928
• UniProt: P25025
• MGI: 105303

CXCR2 (short for CXC motif chemokine receptor 2, and interleukin 8 receptor beta (IL- 8RB ), GRO / MGSA receptor, CDw128b, CD182 ) is a receptor protein of the family of chemokine receptors. CXCR2 is especially at the surface of cells of the immune system such as neutrophils, above. This receptor can be stimulated by the chemokines CXCL1 (GRO- α ), CXCL2 (GRO- β ), CXCL3 (GRO- γ ), CXCL5, CXCL7 and CXCL8 ( interleukin 8) and mediates its effects through activation of an intracellular signal transduction cascade at the Gi proteins are involved. CXCR2 is ascribed an important role in the pathogenesis of inflammatory diseases and tumor growth.

Occurrence

CXCR2 may in particular neutrophils, but also eosinophils, basophils, dendritic cells, T lymphocytes and macrophages are detected.

Biochemistry

CXCR2 is encoded by a gene on the chromosome 2 gene locus q33 - q36.

CXCR2 structurally belongs to the G protein- coupled receptors. After binding of the chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL8 CXCL7 or a signal transduction cascade is activated inside the cell, at the G- proteins, Ca2 and MAP kinases are involved. The signal transduction cascade also includes activation of integrins and changes in the cytoskeleton. These are prerequisites for targeted movement (chemotaxis ) of CXCR2 -expressing cells to a chemokine gradient toward.

Function

CXCR2 plays an important role in the recruitment of leukocytes into the inflamed tissue. In addition, CXCR2 is an important in the formation of new blood vessels (angiogenesis) chemokine receptor involved. This mechanism CXCR2 can promote the growth of tumors.