Isosorbide dinitrate

IUPAC: 3,6- Bisnitrooxyhexahydrofuro [3,2 -b] furan

• C01DA08
• C01DA58

Vasodilator

70 ° C.

Attention

747 mg · kg -1 ( LD50, rat, oral)

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Isosorbide dinitrate (ISDN) is a drug used to treat angina pectoris or coronary atherosclerosis. It improves the oxygen supply to the myocardium while reducing the oxygen consumption of the myocardium, by reducing the so-called preload. Similar effect has isosorbide mononitrate.

Isosorbide dinitrate was synthesized in 1938 by Goldberg glucitol. It is available as a generic by many companies in the trade.

Preparations

Isosorbide dinitrate can be administered in various ways. There are tablets, sprays and prolonged available. The tablet for sublingual administration acts within one minute. The effect lasts for about an hour. If the spray is applied to the oral mucosa, it works just as fast in some, but the effect only lasts half an hour. With a prolonged effect can be achieved up to 12 hours. The effect however occurs only in up to 30 minutes.

Adverse effects

In addition to a flush nitrates can generally trigger a headache caused by vasodilation. Also may occur dizziness. Since the nitrates can lower blood pressure strong, they have to be dosed very careful in systolic pressure below 100 mmHg. Prolonged medication enters a loss of efficacy. This loss of activity can, however, by a nitrate break of at least twelve hours again cancel.

Trade names

Diconpin (D), Isoket (D, A, CH), Isomack (A), iso- meshing (D), Jena Card ( D), Nitrosorbon (D), Sorbidilat (CH), Carvasin (I ), numerous generics (D )

Viskenit (A)