ISREC

The Swiss Institute for Experimental Cancer Research ( Institut suisse de recherche sur le cancer expérimentale, ISREC short ) was founded on 18 June 1964 in the form of a foundation. It has its headquarters in Canton Vaud Epalinges.

Since 1 January 2008, the appearance of ISREC happens in two steps:

  • The ISREC Foundation

With the mandate to support translational cancer research projects and young researchers.

  • The Institute ISREC at EPFL

With research projects, which deal with fundamental questions concerning the development of cancer.

History

The origins of ISREC are in the western Swiss anti-cancer center (Centre Anti- cancéreux Romand of the Canton de Fribourg, Neuchâtel, Valais Vaud et, short CACR ) to search, which was founded in 1924 in Lausanne. Initially, it consisted mainly of three sections: an anatomic pathology department (Service d' anatomy, pathology ), a Department of Experimental Research ( Service of recherches EXPERIMENTALES ) as well as a therapeutic service (Service thérapeutique ). The appointment of Alfredo Vannotti (1907-2002) Head of the Department of Experimental Research in 1947 and the appointment of Serge Neukomm ( * 1917 ) a year later led to a major expansion of experimental research. Nevertheless, the therapeutic service as a medical- social service (Service médico-social ) was further operated in the 1950s. As from 1957, however, cantonal sections of the Cancer League Switzerland were founded in the various CACR associated cantons, the CACR transferred this its medico-social activities. From then on it was limited to the experimental cancer research. Under the direction of Rodolphe Stadler ( Chairman since 1951) and Henri Isliker (Director ) was founded as the ISREC Swiss foundation launched on 18 June 1964.

Initially there was the ISREC close to the Canton Hospital ( Hôpital Cantonal ) and, later, at the Centre Hospitalier Universitaire Vaudois et ( CHUV). Because the ISREC grew steadily and at the beginning of the 1970s, a collaboration with various other research institutions, especially the Ludwig Institute for Cancer Research, the World Health Organization (WHO ) and the Institute of Biochemistry at the University of Lausanne has been made, the existing premises soon proved to small. Therefore, the ISREC built in Epalinges a new research center and moved in the fall of 1976 into this. In 1978, Henri Isliker handed over the reins ISREC Bernhard Hirt, who led the research facility for 18 years. In 1996, the Directorate was transferred to Michel Aguet. In 2008 the Institute was incorporated into the Faculty of Life Sciences at the EPFL, and the Institute is headed since 2009 in a new building at the EPFL by Douglas Hanahan. Regardless of these changes, the ISREC Foundation (President Yves J. Paternot ) leads their efforts continue to provide financial support to promote projects in cancer research that have a broad potential for innovation in both diagnostic and therapeutic aspects.

Research ( focus )

The research activities of the Swiss Institute for Experimental Cancer Research - an independent institution - have focused on the basic research of cancer development during more than 40 years. Since the integration of the research groups of the Institute in the EPFL - Faculty of Life Sciences on January 1, 2008 and the partial renewal of the academic staff research focuses at the Institute mainly on issues such as the stability of the genome, the division, proliferation and differentiation of cells, and the role of signaling pathways in tumorigenesis and tumor progression.

Publications

Since 1964 the research activity led at ISREC for the publication of more than 2,000 scientific articles and among these were many publications in Cell, Nature, Science and specialized magazines of Nature.

Awards (selection)

Research at ISREC was awarded many prizes. Prize winners were, inter alia:

  • Marcel Benoist Prize:
  • Friedrich Miescher Price:
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