James O'Brien
James O'Brien is the name of:
- James O'Brien ( congressman ) ( 1841-1907 ), American politician
- James O'Brien ( botanist ) ( 1842-1930 ), British botanist
- James O'Brien ( footballer ) (* 1987), Irish footballer Scottish origin
- James Bronterre O'Brien (1805-1864), Irish labor leader
- James H. O'Brien (1860-1924), American politician
- James Joseph O'Brien (1930-2007), British clergyman, Auxiliary Bishop of Westminster
- Disambiguation