James Wade began his professional career in 2001 in the World Darts Federation. In 2004, he joined the Professional Darts Corporation. In 2007, Wade the World Matchplay win after victories over Dennis Priestley, Mervyn King, Adrian Lewis and Terry Jenkins. Three months later, the victory came at the World Grand Prix. In January 2009 he was in the semifinals of the World Professional Darts Championship, where he lost 4:6 against Raymond van Barneveld. In May 2009 he won the Darts Premier League by a final victory against Mervyn King with 13:8. In 2010, James Wade again reached the final of the Premier League Darts, but could not defend his title because he lost in the final against Phil Taylor with 8:10. In October 2010, Wade won the Grand Prix in Dublin against Adrian Lewis in the final 6 to 3 sets. At the World Cup 2011 James Wade lost in the second round against the Austrian Mensur Suljović 2-4. On June 5, 2011 Wade won the PDC UK Open by a 11-8 final victory against Wes Newton. His theme song is " Bonkers " by Dizzee Rascal ft. Armand Van Helden.
James Wade suffers from bipolar disorder. Since 2011, he speaks openly about his illness.