Jesaya Nyamu was in political exile since 1964, the first led him to Tanzania and then to the U.S., where he studied economics at the University of California. After his graduation he studied in the USSR also economics. His diplomatic career began with work as SWAPO 's representative in Tanzania and Zambia. From 1976 to 1980 he was Deputy Secretary for Information in Luanda, Angola. Subsequently, he was SWAPO representative in Addis Ababa, Ethiopia. After the independence of Namibia in 1990 Nyamu was deputy secretary of state, joined in 1991 as a Deputy Minister in the Ministry of Mines and Energy and from 1999 to 2002 the same as a minister.
After he was opposed openly against SWAPO and the management style of the then President Samuel Nujoma, he was expelled from the party in 2002. The text written by him "on how to break President Sam Nujoma 's rule, including by forming a new political party " gave him no perspective in the ruling party. In 2007 he was co-founder of the Party Rally for Democracy and Progress, on whose party congress in 2008, he was confirmed as party general secretary.