John McKee attended Liberty Hall Academy (now Washington and Lee University ) in Lexington ( Virginia). Then he was in charge 1802-1816 as a U.S. Representative to the Choctaw Indians in the eastern part of the Mississippi River. On March 9, 1821 he was appointed to an official in the land registry in Tuscaloosa. He was also one of the first settlers in Tuscaloosa County.
McKee was a member of the Commission, which laid down the boundary curve between the U.S. states of Kentucky and Tennessee. He was elected as a Jackson Republican to the 18th U.S. Congress and reelected to the two succeeding U.S. Congresses. There he served in the U.S. House of Representatives from March 4, 1823 to March 3, 1829. He decided in 1828 against a candidacy in the 21th U.S. Congress. After that, he was in 1829 one of the commissioners who negotiated the Treaty of Dancing Rabbit Creek, through which a large part of the country west of the Tombigbee River was acquired from the Choctaw Indians.
John McKee died in 1832 then buried at home on the Hill of Howth, and was on the Bethsalem Cemetery, Boligee (Alabama ).