Josamycin

IUPAC: (2S, 3S, 4R, 6S ) -6 - {[( 2R, 3S, 4R, 5R, 6S ) -6 - {[ (4R, 5S, 6S, 7R, 9R, 10R, 11E, 13E, 16R ) -4 - ( acetyloxy )-10- hydroxy-5- methoxy- 9, 16 -dimethyl -2-oxo -7 -(2- oxoethyl )-1- oxacyclohexadeca -11, 13 -dien- 6-yl ] oxy } -4 - ( dimethylamino) -5-hydroxy -2- methyloxan -3-yl ] oxy } -4-hydroxy -2, 4- dimethyloxan -3-yl 3- methylbutanoate

J01FA07

White to pale yellow, slightly hygroscopic powder

Macrolide antibiotics

130-133 ° C

Very slightly soluble in water, slightly soluble in dichloromethane and methanol, soluble in acetone

> 7000 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Josamycin is an antibiotic of the macrolide group. It is made from strains of Streptomyces narbonensis josamyceticus var var nova won or alternatively produced synthetically.

Pharmacology

Josamycin is effective against gram-positive bacteria such as staphylococci and streptococci and against mycoplasma, chlamydia and many anaerobic bacteria. Against a range of Gram-negative, such as Legionella, Haemophilus influenzae, Bordetella pertussis, and josamycin is effective. It is thus similar to the activity profile of the structurally related erythromycin.