Josef Zisyadis was born in Istanbul, the son of Greek parents. Soon his family moved to Athens. In 1963 he moved to Switzerland, to Lausanne, where he graduated from high school and then studied theology. Subsequent to the study, from which he graduated in 1979 with a degree, he spent four years as a pastor in Belleville in Paris.
From 1983 to 1994 he worked as secretary of the Parti Ouvrier Populaire Cantonal the canton of Vaud from 1994 to 1996 as Secretary of the mother party PdA Switzerland. Since 1998 he has been a political secretary at the POP Vaud.
1996 to 1998 he was State Council of the Canton of Vaud and directed the judiciary, police and military department.
Since the elections of 1999 he sat for the Labour Party in the National Council, which he already belonged from 1991 to 1996. In the elections of October 21, 2007 Josef Zisyadis was voted out, but since the selected party member Marianne Huguenin gave up her seat, Zisyadis moved by. Four years later, at the Swiss parliamentary elections in 2011, he no longer went to and retired from the National Council of.
To complain against the new tax law of the Canton of Obwalden, he has taken up residence in Sachseln on 27 February 2006. Since then but three Obwaldner were found, which led the action, he moved on 1 May 2006 back in the canton of Vaud.
Zisyadis was involved in the founding of the alternatives left, and was listed as the National Council from 2010.