Juvenile polyposis syndrome

When juvenile polyposis syndrome ( JPS ), also referred to as juvenile polyposis, results in the formation of so-called hamartomatous polyps ( polyp, hamartoma tumor ), but those are mostly localized in the area of the colon and the rest of gastrointestinal tract concern may be.

Juvenile polyps are the most common polyps in childhood. In the majority is sporadic solitary polyps. In a small part, however, the polyps are a symptom of an autosomal dominant hereditary disease known as Familial Juvenile Polyposis ( FJP ), which is caused by mutations in the regulatory protein MAD homolog 4.

Pathophysiology and Pathology

The juvenile polyps show on the surface hyperplastic inflammatory mucosal changes and are generally considered benign. In rare cases, the transition into real adenomatous polyps ( colorectal adenomas) that are associated with an increased risk of colorectal cancer. Regular colorectal cancer screening is particular in familial progressive form therefore recommended that should involve the entire gastrointestinal tract.