Karl Barry Sharpless

Karl Barry Sharpless ( born April 28, 1941 in Philadelphia ) is an American chemist and Nobel laureate.

Life and work

He studied at Dartmouth College, received his doctorate in 1968 at Stanford University and continued his research continued, before moving to Harvard University in 1969.

Sharpless became a professor at the Massachusetts Institute of Technology, Stanford University and later at the Scripps Research Institute, where he holds the WM Keck Professor since 1990.

He received the Nobel Prize in Chemistry for his work on stereoselective oxidation reactions ( Sharpless epoxidation, Sharpless bishydroxylation, Sharpless aminohydroxylation ) in 2001. The price he shared with William S. Knowles and Ryoji Noyori ( for her work on the stereoselective hydrogenation ). He holds honorary doctorates from the Technical University of Munich.

He currently works primarily on the emerging field of click chemistry, these are selective exothermic reactions that proceed under mild conditions in water. An example is the alkyne - azide (3 2 ) cycloaddition with formation of 1,2,3- triazoles. Since 2013 it is one of Thomson Reuters due to the number of its citations to favorites to a (re ) Nobel Prize (Thomson Reuters Citation Laureates ).

Work areas

Click chemistry, transition metal -catalyzed asymmetric reactions catalyzed oxidation reactions (Os, Ru, Rh)