Kozak consensus sequence

The Kozak sequence and eng. Kozak consensus sequence called, is a named after American biochemist Marilyn Kozak nucleic acid sequence in the messenger RNA ( mRNA) of eukaryotic organisms. It represents a consensus of the most commonly occurring nucleic bases in the immediate vicinity of the start codon on the mRNA August dar. As a Kozak sequence is often the base sequence (gcc ) gccRccATGG called, where there are significant differences between different groups of eukaryotes. The Kozak sequence or a similar Nukleinbasenfolge is recognized by the ribosome and for initiation of translation in the context of the protein is important. Deviations in the Nukleinbasenfolge can have an impact on protein biosynthesis.

Variations

Among eukaryotes several variations of the Kozak sequence dominate.