Levocetirizine

• (R) -2 - (( 4 - (4 -chlorophenyl) - phenylmethyl) - 1 - piperazinyl) ethoxyacetic acid
• (-) -2 - ( (4 - ( 4-chlorophenyl) - phenylmethyl) - 1 - piperazinyl) ethoxyacetic acid
• L-2 -(( 4 - (4 -chlorophenyl) - phenylmethyl) - 1 - piperazinyl) ethoxyacetic acid

• C21H25ClN2O3 [ cetirizine ]
• C21H25ClN2O3 · 2 HCl [ cetirizine dihydrochloride · ]

R06AE09

The antihistamine ethylenediamine - type

Template: Infobox chemical / molecular formula search available

Levocetirizine is a drug from the group of antihistamines, which is used for the symptomatic treatment of allergic diseases. Stereochemistry is the active enantiomer levocetirizine ( eutomer ) of cetirizine.

Levocetirizine was first launched in early 2001 by the Belgian company UCB as an effective ingredient of a drug under the name Xusal in the trade. The first registered in Germany.

Clinical information

Areas of application (indications )

Levocetirizine is licensed for the symptomatic treatment of allergic rhinitis and prolonged idiopathic urticaria.

A superiority over the parent drug cetirizine regarding the efficacy of levocetirizine can be due to the lack of comparative studies so far do not clearly show even if some studies suggest.

Adverse effects (side effects)

• Common: headache, somnolence, dry mouth, fatigue.
• Uncommon: malaise, abdominal pain.
• Rare: hypersensitivity reactions including anaphylaxis, dyspnea, nausea, angioedema, pruritus, rash, urticaria, weight gain, palpitations, blurred vision, hepatitis, elevated liver function tests, aggressiveness, agitation, seizures, muscle pains.

Trade names

Levocetirizine is the active ingredient of the following medicines: Xusal (DE), Xyzall (AT), Xyzal (CH) and various generics (D, A, CH).