Lewy body

Lewy bodies (English: Lewy bodies ) are characteristic structures that are detectable in the brain tissue of patients who have suffered during the lifetime of Parkinson 's disease or a dementia of Lewy body type. It is to round cytoplasmic inclusion bodies of the nerve cells. They usually have a dense eosinophilic core and a pale halo. They consist of α -synuclein, ubiquitin, neurofilament protein and other deposits.

Lewy bodies were first placed with Parkinson 's disease in combination in 1912 by the neurologist Friedrich H. Lewy ( 1885-1950 ). Their ultrastructure was first described in 1965 by Duffy and Tennyson. While found in Parkinson 's disease Lewy bodies in neurons of the substantia nigra, they occur in Lewy body dementia among others in the brainstem and cerebral cortex.

Original work

• E. Forster and F. H. Lewy. " Palsy ". In Pathological Anatomy. Handbook of Neurology (edited by M. Lewandowsky ). Berlin: Springer Verlag 1912, 920-933.
• Duffy PO, Tennyson VM: Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus coeruleus in Parkinson 's disease. J. Neuropathol. Exp Neurol. 24: 398-414, 1965

• Examination findings in neurology
• Pathology