Lipoxygenase

Lipoxygenases are enzymes which oxidize several times unsaturated fatty acids having two oxygen atoms. They thus belong to the group of dioxygenases. Various lipoxygenases play a role in the arachidonic acid metabolism of mammals and in the plant linoleic acid metabolism, among others. Enzymes have up to three iron ion in their catalytic site as a cofactor.

Among the lipoxygenases

  • Plant lipoxygenases ( EC 1.13.11.12 ), in the cytosol and in chloroplasts
  • Arachidonate 5 -lipoxygenase of mammals ( EC 1.13.11.34 )
  • Arachidonate 12 -lipoxygenase of mammals ( EC 1.13.11.31 )
  • Arachidonate 15 -lipoxygenase of mammals ( EC 1.13.11.33, only in the erythrocytes ) and of Pseudomonas aeruginosa
  • The bifunctional Allenoxidsynthase/Archidonat-8-Lipoxygenase coral Plexaura ( EC 1.13.11.40 )
  • The linoleate 11- lipoxygenase in plant and fungus Gaeumannomyces graminis ( EC 1.13.11.45 )
Cofactor (biochemistry)
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