Lofepramine

N06AA07

Antidepressants

104-106 ° C

Attention

  • 920 mg · kg -1 ( LD50, mouse, ip)
  • > 5000 mg · kg -1 ( LD50, rat, oral)

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Lofepramine is a chemical compound from the class of dibenzazepines, which is used as a drug for the treatment of depression. It belongs to the group of drugs called tricyclic antidepressants.

The drug was patented in 1970 and 1972 by the Swedish corporation Leo ( Leo Läkemedel AB) and was in Germany under the trade name Gamonil ® from Merck on the market.

Clinical information

The mean daily dose of lofepramine is between 70 and 210 mg.

Pharmacological properties

Lofepramine is structurally a derivative of imipramine, which is metabolized to the active metabolite desipramine. Is used, the drug in the form of its hydrochloride.

The substance inhibits the reuptake of norepinephrine from the synaptic cleft significantly stronger than that of serotonin. Lofepramine also acts as FIASMA ( functional inhibitors of acid sphingomyelinase ).

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Intraperitoneal injection Active ingredient Major depressive disorder Digital Object Identifier
527235
de