Loprazolam

(2Z)-6-(2-Chlorphenyl)-2-[(4-methyl-1-piperazinyl)methylen]-8-nitro-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-on

N05CD11

Template: Infobox chemical / molecular formula search available

Loprazolam is a benzodiazepine of moderately long duration of action. The indications, contraindications and interactions are similar to those of all benzodiazepines. It can lead to psychological and physical dependence after a short application. Monopreparations include Dormonoct, Havlane, Sonin, Somnovit (in various forms up to 2 mg). Loprazolam is mainly used as a hypnotic but also as a sedative. In Germany the last preparation with Loprazolam ( Sonin ) was taken off the market in January 2006.

Dose

The dose of Loprazolam insomnia is usually from 1 mg, but can be increased to 2 mg, if needed.

Side effects

The side effects generally similar to those of other benzodiazepines. In Loprazolam the following occur most frequently:

• Somnolence
• Paradoxically, increased aggression
• Dizziness
• Confusion
• Muscle weakness
• Ataxia ( especially in the elderly )
• Amnesia
• Headache
• Hypotension
• Blurred vision
• Dysarthria
• Tremor
• Altered libido
• Jaundice
• Rash
• Dependence

Legal status

Loprazolam was included ( negotiable and prescription narcotics ) in the Federal Republic of Germany due to its performance in the Appendix III of the Narcotics Act ( Narcotics ). More information can be found in the main article narcotics law in Germany.