The serine / threonine kinase LRRK2 (more precisely: Leucinreicher-Repeat-Serin/Threoninkinase 2; dardarin also, from the Basque word for tremble dardara ) is an enzyme that provides other proteins with a phosphate group, a so-called protein kinase. Protein kinases of this type are found in all eukaryotes. In humans dardarin is found in many tissues, especially in large quantities but in dopamine- sensitive areas of the brain. Mutations in the LRRK2 gene may cause familial Parkinson 's disease.

It is not yet known which proteins are phosphorylated by dardarin.

About one to five percent of sporadic and five to ten percent of familial cases of Parkinson's disease are caused by mutations in LRRK2. One specific mutation, the amino acid glycine to serine change in 2019 ( G2019S ), it is of particular importance. 20 to 30 percent of Parkinson's cases in the population of Ashkenazi Jews as the north African population can be explained by this mutation. Currently, over 20 different mutations have been identified in more than 100 families.

LRRK2 is located on chromosome 12