Weiser studied computer science and communication studies at the University of Michigan (MA 1977, Ph.D. 1979). He lectured at the University of Maryland, College Park.
Until his death he was at Xerox Research Center in Palo Alto, California, shortly PARC busy. He became famous for his essay The Computer for the 21st Century of 1991, in which he describes how he, the computer and the world of computer imagines in the middle or at the end of the 21st century. There he mentioned as first used the term " ubiquitous computing ". In his essay, among others, a normal morning is portrayed in the life of Sal, who lives in a smart home with their children. Here, among others, come then still uncommon and (then) adjacent to science fiction technologies such as tablets used.