Woodforde began his career in 1984. During his career, he won four individual titles, including the professional tournament in his hometown of Adelaide. In doubles, he won 12 Grand Slam tournaments, including eleven on the side of Todd Woodbridge, also he triumphed in 1989 with John McEnroe in doubles competition of the U.S. Open.
Together with Todd Woodbridge, he formed one of the most successful men's doubles in tennis history. In public, the two The Woodies were called. With partner Woodbridge, he won 61 doubles tournaments. Moreover, the two in 1996 won the gold medal at the Atlanta Olympics and the silver medal at the 2000 Olympic Games in Sydney.
In mixed, he won five more Grand Slam titles.
With Australia, he was able to move in three Davis Cup finals and win the final against France in 1999. It was the first victory for Australia is a 13 -year losing streak.
After his career end in 2000, Mark Woodforde was coach of the Australian Fed Cup team. Since 2007, he also oversaw temporarily Novak Djokovic.
On March 1, 2010 Woodforde was officially nominated for induction into the International Tennis Hall of Fame.