Markus Affolter

Markus Affolter ( born June 3, 1958 in Seeberg ) is a Swiss developmental biologist and research at the Biozentrum, University of Basel.

Life

Markus Affolter studied biology at the ETH Zurich and at Laval University in Quebec City, Canada. Following his PhD at Laval University, he went in 1988 as a postdoctoral fellow to the Biozentrum, University of Basel. In the laboratory of Walter Gehring, Markus Affolter began his research with the fruit fly Drosophila melanogaster. In 2000 he became Assistant Professor in 2005 and Full Professor of Developmental Biology at the Biozentrum, University of Basel.

Work

Markus Affolter explores the cellular and molecular processes involved in the formation of organs and blood vessel networks in the fruit fly Drosophila melanogaster and the zebrafish. Markus Affolter to document the basis of live - imaging studies network formation in Drosophila and in zebrafish using high-resolution microscopy live succeeded. This now makes it possible to better understand the function of molecules in morphogenesis. In addition, his lab showed in collaboration with the University of Freiburg, Germany, and the University of Lausanne, Switzerland, that the morphogen Dpp and the feedback control pentagons key functions in tissue growth proportional (scaling ) take over in the wing disc of the fruit fly.

Awards

Publications (selection )

  • Lenard, Anna; Ellertsdóttir, Elin; Herwig, Luke; Krudewig, Alice; Belting, Heinz -Georg; Affolter, Markus ( 2013). In Vivo Analysis Reveals A Highly stereotypic Morphogenetic Pathway of Vascular Anastomosis. In Dev Cell, 25 ( 5), 492-506.
  • Caussinus, Emmanuel; Kanca, Oguz; Affolter, Markus ( 2011). Fluorescent fusion protein knockout mediated by anti -GFP antibody nano. In Nat Struct Mol Biol, ( 19), 117-121.
  • Hamaratoglu, Fisun; Morton de Lachapelle, Aitana; Pyrowolakis, George; Bergmann, Sven; Affolter, Markus ( 2011). Dpp Signaling Activity Requires pentagons to Scale with Tissue Size in the Growing Drosophila Wing Imaginal Disc in PLoS Biol, 9 (10 ), e1001182.
  • Herwig, Luke; Blum, Yannick; Krudewig, Alice; Ellertsdóttir, Elin; Lenard, Anna; Belting, Heinz -Georg; Affolter, Markus ( 2011). Distinct Cellular Mechanisms of Blood Vessel Fusion in the Zebrafish embryo. Curr Biol, 21 (22) 1-7.
  • Weiss, A.; Charbonnier, E.; Ellertsdóttir, E.; Tsirigos, A.; Wolf, C.; Shoe, R.; Pyrowolakis, G.; Affolter, M. ( 2010). A conserved activation element in BMP signaling falling on Drosophila development. In Nat Struct Mol Biol, 17 ( 1), 69-76.
  • Caussinus, E.; Colombelli, J.; Affolter, M. ( 2008). Tip -cell migration controls stalk -cell intercalation falling on Drosophila tracheal tube elongation. Curr Biol, 18 (22), 1727-1734.
  • Cabernard, C. and Affolter, M. ( 2005). Distinct Roles for Two Receptor Tyrosine Kinases in Epithelial Branching Morphogenesis in Drosophila. In Dev Cell 9, 831-842
  • Pyrowolakis, G.; Hartmann, B.; Müller B.; Basler, K. and Affolter, M. ( 2004). A simple molecular complex mediates wide spread BMP -induced repression falling on Drosophila development. In Dev Cell. 7, 2229-2240.
  • Jaźwińska, A.; Ribeiro, C. and Affolter, M. ( 2003). Piopio and Dumpy, two apically secreted proteins, are required for tracheal tube remodeling falling on morphogenesis in Drosophila. In Nat Cell Biol 5, 895-901.
  • Müller, B.; Hartmann, B.; Pyrowolakis, J.; Affolter, M. and Basler, K. ( 2003). Conversion of gradient of extracellular Dpp / BMP morphogen gradient into at inverse transcriptional. In Cell 113, 221-233.
  • Ribeiro, C.; Ebner, A. and Affolter, M. ( 2002). In Vivo Imaging Reveals Different Cellular Functions for FGF and Dpp signaling in tracheal branching morphogenesis. In Dev Cell 2, 677-683.
  • Marty, T.; Müller, B.; Basler, K. and Affolter, M. ( 2000). Schnurri mediates Dpp -dependent repression of brinker transcription. In Nat Cell Biol 5, 359-369.
  • Grieder, N.C.; Nellen, D.; Burke, R.; Basler, K. and Affolter, M. ( 1995). schnurri is required for Drosophila Dpp signaling and Encodes a zinc finger protein similar to the mammalian transcription factor PRDII - BF1. In Cell 81, 791-800.
  • Ruberte, E.; Marty, T.; Nellen, D.; Affolter, M. and Basler, K. (1995). An absolute requirement for Both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo. In Cell 80, 889-897.
  • Nellen, D.; Affolter, M. and Basler, K. (1994). Receptor serine / threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. In Cell 78, 225-237.
Walter Jakob Gehring Organ (anatomy)
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