Mebendazole

• Methyl-5 -benzoyl -2- benzimidazole carbamate
• 5 -benzoyl -2- methyl ester benzimidazolcarbaminsäure
• N-[ 6 - ( benzoyl) -1H- benzimidazol-2 -yl] methylcarbamate

P02CA01

Anthelmintic

288-289 ° C

Very poor in water ( 71.3 mg · l-1 at 25 ° C)

Attention

714 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Mebendazole ( Vermox ® trade names among others; initial manufacturer Janssen Pharmaceutica ) is a drug from the group of benzimidazoles, which is used as a vermifuge in the treatment of worm infestations.

Clinical information

Mebendazole drugs are approved for treatment of patients with intestinal worm infections by nematodes and some tapeworms (tablets of 100 mg ) and cystic echinococcosis, alveolar echinococcosis and trichinosis ( 500 mg tablets ). Mebendazole is also used in veterinary medicine in a variety of worm infestations. Contraindicated are the means with hypersensitivity to any of its ingredients. Concomitant administration of mebendazole and metronidazole should be avoided. Mebendazole is teratogenic in rodents; use during pregnancy usually does not come into question.

The most common side effects include occasional headache, dizziness, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting.

Pharmacological properties

Mebendazole binds to microtubules in the intestines of worms, which then leads to the degeneration and disruption of glucose uptake. Mammalian cells are not affected.

The absorption of mebendazole after oral administration is incomplete and by a strong first-pass effect, a large part of the drug is eliminated, so that only a small proportion of the dose is bioavailable.

The drug was developed in the early 1970s at Janssen Pharmaceutika.

Trade names

VERMOX (A), Surfont (D), Vermox (D, CH) In veterinary medicine, it is sold under the name Mebentab Telmin and paste, as a combined preparation with Closantel ( Closantel sodium 2H2O) as Flukiver Combi.