In 1990 she received a voice in the animated film Earthday Birthday. Then she played the role of Mallory Pike in eleven episodes of the series The Baby - Sitters Club. In twelve episodes of the situation comedy show The Chaos Clan, she played the role of beauty Weed. For this performance she was nominated it for a Young Artist Award in the year. In the first episode of the sixth season of Law & Order, she stood in a small role in front of the camera. From 2004 to 2005 she appeared twice in the soap opera Guiding Light as a Tara LEDOM. In 2007, a guest appearance followed in offshoot of Law & Order, Criminal Intent - Criminal Intent. In the sci- fi thriller The plan by George Nolfi Andrews played a Receptionist. She can be seen alongside Matt Damon and Emily Blunt. In the same year she played the role of Jill in the crime series Justified.
Besides her work in films and television series, Meghan Andrews also played at the off-Broadway in such plays as Clocks and Whistles (2006) the female lead or on Broadway in the play Frost / Nixon (2007) with Frank Langella and Michael Sheen.
Aside from acting, Meghan Andrews brought out in 2006 a music CD. She sings the songs in folk.