Melanocortin 1 receptor

The melanocortin receptor 1 ( MC1R ) is one of the melanocortin receptors, and is a human gene locus on chromosome 16 Q24.3 encoded transmembrane G- protein coupled receptor which is expressed in melanocytes and controls the scald. There are over 30 different receptor alleles that determine the skin type ( sensitivity to skin exposure and sunburn). A specific mutation leads to hereditary susceptibility to malignant melanoma.

The locus of this receptor is called the Extension locus.

Human Genome Organisation
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