Melanocortin 3 receptor

• OMIM: 155 540
• UniProt: P41968

The melanocortin receptor 3 (abbreviated MC3R ) belongs to the group of the melanocortin receptors, and is a G- protein coupled receptor. It is expressed in the brain ( there especially in regions of the hypothalamus near the organum vasculosum laminae terminalis), the placenta, the intestinal tissue but not expressed in the adrenal cortex or in melanocytes. Activated by α -MSH, β -MSH, γ -MSH and ACTH, and involved in autonomic regulation of Energiehomösostase for example in the suppression of the febrile response, or to influence the utilization of food with reduced Körperfettanlagerung and counter-regulation to the metabolic syndrome (see OMIM ).

Genetics

The MC3R is encoded on chromosome 20q13.2 - q13.3 section and contains 360 amino acids.