Meloxicam

4-hydroxy -2-methyl -N-( 5-methyl -2- thiazolyl) - 2H -1 ,2- benzothiazine -3-carboxamide -1 ,1-dioxide

M01AC06

Nonsteroidal anti-inflammatory

Cyclooxygenase inhibitors

254 ° C.

4.08

Water: 7.15 mg · L-1 at 25 ° C

Risk

84 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Meloxicam is a drug, specifically a nonsteroidal anti-inflammatory ( NSAID NSAID) from the group of Oxicams. It is a pale yellow, almost insoluble in water powder.

Mechanism of action

As with all NSAIDs inhibit cyclooxygenases, meloxicam ( COX), and it has a slightly selective COX-2 activity and therefore less severe side effects that may occur especially in compounds with COX-1 preference.

In addition, meloxicam reduces the migration of leukocytes into inflammatory sites. Platelet aggregation is only slightly inhibited.

Meloxicam can be used both orally and subcutaneously. It is rapidly absorbed. Plasma protein binding is 99.4 percent, the plasma half -life of 15-20 hours. The reduction takes place in the liver by the enzyme CYP2C9, excretion via the bile (and thus the faeces ) and urine.

Application

Meloxicam is especially in chronic joint diseases applied (arthritis, arthrosis ), because it accumulates in the synovial fluid. However, it can also be used for other painful processes ( gout, ankylosing spondylitis, rheumatism) and for pain therapy before and after surgery.

This medication should not be used in diseases of the stomach or intestinal mucosa, kidney failure, bleeding disorders and children or very young animals (<6 weeks). In late pregnancy or gestation, the agent is contraindicated.

Side effects

As with all NSAIDs, meloxicam can cause disorders of the gastrointestinal tract ( ulcers, loss of appetite, diarrhea, vomiting), blood coagulation and renal function. Also intolerance reactions or skin changes may occur.

Production

The synthesis starting from saccharin described in the literature.

Trade names

Metosan (A), Mobic (D), Mobic (A), Mobicox (CH), Movalis (A) Loxitane (GR ), numerous generics (D, A)

Veterinary medicine: Animeloxan, Inflacam, Loxicom, Meloxivet, Metacam, Rheumocam