Mesial temporal sclerosis

The mesial temporal sclerosis, also known as hippocampal sclerosis or hippocampal sclerosis, is the most common neuropathological findings in intractable temporal lobe epilepsy. Histologically, the mesial temporal sclerosis is characterized by nerve cell loss in the hippocampal formation, according to their distribution patterns can be distinguished four different types. While the classic form of hippocampal sclerosis ( Typ1A after Blümcke ) and the severe hippocampal sclerosis (type 1B according Blümcke ) have a favorable prognosis, may in an atypical distribution pattern of nerve cell failures in the CA2, CA3 and CA4 region ( Endblattsklerose, Blümcke type 3) are obtained after epilepsy surgery rare seizure freedom.