Metabolic Control Analysis

Metabolic Control Analysis (MCA ) is a calculation method by which the concentrations and fluxes of the various intermediates can be analyzed, resulting in a network of metabolic processes of recording up to the departure of the final product.

The Basics of Metabolic Control Analysis were independently developed in the early 1970s by Reinhart Heinrich and Tom Rapoport at the Humboldt University in Berlin and Henrick Kacser and Jim Burns at the University of Edinburgh and published.


  • Fell D. Understanding the Control of Metabolism, Portland Press, 1997.
  • Henry R. and S. Schuster, The Regulation of Cellular Systems, Chapman and Hall, 1996.
  • Analytical Chemistry
  • Biochemical method
  • Metabolism