Mevalonate kinase

The mevalonate kinase (MK) is the enzyme that catalyzes the phosphorylation of mevalonate in eukaryotes, a sub-step in the biosynthesis of isoprenoids. MK is localized in the cytosol of peroxisomes. In humans, mutations in the MVK gene can cause hereditary mevalonate kinase deficiency and Hyperimmunoglobulinemia D type.

Catalyzed reaction

ATP ADP ⇔

R- mevalonate is converted to 5 -phospho -R - mevalonate.

Human Genome Organisation Mevalonic acid
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