Mevastatin

  • Compactin
  • [( 1S, ​​7S, 8S, 8aR ) - 8 - [2 - [( 2R, 4R ) - 4 - hydroxy-6- oxooxan -2-yl ] ethyl]- 7-methyl- 1,2,3,7, 8,8 a - hexahydronaphthalen -1-yl ] (2S )-2- methylbutanoate

Colorless crystals

Statins

HMG-CoA reductase inhibitor

152 ° C

  • Insoluble in water ( 4.8 mg · l-1 at 25 ° C)
  • Soluble in methanol and acetone

> 2000 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Mevastatin, also compactin, is a drug from the group of statins for the treatment of dyslipidemia. It was the first HMG -CoA reductase inhibitor that was in the 1970s isolated from Penicillium citrinum.

Mevastatin is not used in the treatment of dyslipidemia, as it has many side effects. However, it is used as a starting compound for the preparation of other statins, such as pravastatin.

CAS registry number PubChem
199017
de