Midodrine

• (±) -1 - (2,5 -dimethoxyphenyl ) -2 - glycinamidoethanol
• 2-amino- N-[2 - (2,5- dimethoxyphenyl ) -2 - hydroxyethyl ] acetamide (IUPAC)

• 42794-76-3 ( midodrine )
• 3092-17-9 ( midodrine hydrochloride · )

C01CA17

Sympathomimetic

α1 -adrenoceptor agonist

Risk

68.8 mg · kg -1 ( LD50, Rat, oral, hydrochloride)

Template: Infobox chemical / molecular formula search available

Midodrine (trade name Gutron ®) is a drug which is used for the treatment of hypotensive circulatory disorders (orthostatic hypotension). It is a prodrug, its metabolite represents desglymidodrine the actual active ingredient.

The drug is applied in the form of its hydrochloride.

Chemical structure

Midodrine contains the basic structure of 2- phenylethylamine, the epinephrine and norepinephrine also underlies the body's neurotransmitters.

Pharmacokinetics and effect

By amide cleavage ( Deglycinierung ) results in the organism from the precursor midodrine the active substance desglymidodrine. It can cross the blood- brain barrier overcome difficult. Desglymidodrine is an agonist at α1 -adrenoceptors (direct sympathomimetic ) and causes an increase in the tonus of the arterial and venous vascular smooth muscle, thereby increasing blood pressure ( vasoconstriction ).

Trade names

Gutron (A)