Minimum inhibitory concentration

Minimum inhibitory concentration (MIC) (English MIC for Minimal Inhibitory Concentration ) is a term from biology. It refers to the lowest concentration of a substance, in which the multiplication of microorganisms can not be perceived with the naked eye.

The MIC is determined by a so-called Titerverfahren.

Usually the concentration of an antibiotic is determined which just inhibits growth of a bacterial strain. The MIC is in micrograms per milliliter ( g / ml ) given (usually in log2 steps ) that checked for quality control seeding density of bacteria is measured in colony forming units per milliliter ( CFU / ml).

For example, the MIC50 is the lowest concentration of a substance which inhibits the growth of at least 50% of the strains tested.

Antibiotics may be further characterized on the minimal bactericidal concentration (MBC ).

  • Microbiological test method
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