Monobactam

Monobactams (eg, aztreonam and Tigemonam ) are drugs that are used as antibiotics.

Preparation and Structure

Monobactams are semisynthetic antibiotics. They are produced by gram-negative bacteria and subsequently synthetically modified. They contain - as many other β -lactam antibiotics - a monocyclic β -lactam ring but no further fused ring.

Application

Monobactams are β -lactamase - stable, but are of extended-spectrum β -lactamases (ESBL ) split. They are not absorbed from the gastrointestinal tract and must be administered parenterally. Their spectrum of activity includes only gram-negative pathogens. They show no effect of anaerobic and Gram- positive bacteria. Their therapeutic application is usually limited to people with penicillin and cephalosporin allergy.