Monoiodotyrosine

• 3-iodo -L-tyrosine
• (S )-2- amino-3- (4- hydroxy-3- iodophenyl ) propanoic acid

White solid

Fixed

205 ° C.

Template: Infobox chemical / molecular formula search available

Monoiodtyrosin (MIT), also outdated monoiodotyrosine ( MJT), is a non- proteinogenic amino acid, which arises from the proteinogenic amino acid L- tyrosine by iodination. It is inside the human body, the precursor of thyroid hormones triiodothyronine (T3) and thyroxine ( T4).

Biological Significance

→ Main article: Thyroid hormones - formation and release

Biosynthesis (Human)

Monoiodtyrosin is formed in the thyroid gland of L- tyrosine and iodide. The L- tyrosine is present here in the form of bound to thyroglobulin tyrosyl residues and the iodide by the enzyme thyroid peroxidase (TPO ) bound to the tyrosyl residues; initially formed by binding an iodine atom Monoiodtyrosin, by binding of another iodine atom then diiodotyrosine (DIT ). Since the TPO contains heme as a prosthetic group, the synthesis of MIT and DIT ( and consequently the thyroid hormones) may be limited by a lack of iron.

Hormone precursor (Human)

Monoiodtyrosin in humans is one of the precursors of the thyroid hormone triiodothyronine (T3) and, by means of diiodotyrosine, the indirect precursor of thyroid hormone L- thyroxine ( T4).