Moracizine

N-[ 10 - (3- morpholin-4- ylpropanoyl ) phenothiazin -2-yl ] ethylcarbamate

  • C22H25N3O4S ( Moricizin )
  • C22H25N3O4S · HCl ( Moricizin · hydrochloride)
  • 31883-05-3 ( Moricizin )
  • 29560-58-5 ( Moricizin · hydrochloride)

C01BG01

Antiarrhythmic

  • 427.52 g · mol -1 ( Moricizin )
  • 463.98 g.mol -1 ( Moricizin · hydrochloride)

6.4 ( Moricizin )

Soluble in water and ethanol ( Moricizin · hydrochloride)

  • 36 mg · kg -1 ( LD50, mouse, i.v. hydrochloride)
  • 12 mg · kg -1 ( LD50, rat, i.v. hydrochloride)

Template: Infobox chemical / molecular formula search available

Moricizin is a drug from the group of antiarrhythmic drugs, used to treat heart rhythm disorders. As sodium channel blockers have no effect on the duration of the action potential, there is the class Ic Vaughan / Williams classification counted. In Europe Moricizin is no longer authorized.

Especially feared are possible paradoxical pro-arrhythmic effects of Moricizin, since in the CAST study Moricizin Although a significant reduction of ventricular premature beats, but a non-significant increase in total mortality of 5.4 to 7.2 percent was observed.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Active ingredient Premature ventricular contraction
582298
de