Multiple organ dysfunction syndrome

Multi-organ failure (MOF; Also: MODS: Multi- organ dysfunction syndrome; MOF: Multi- organ failure ) refers to the simultaneous or sequential failure or serious impairment of various vital organ systems of the body.

The term MOV applies in professional circles now obsolete and has been replaced by MODS. ( ACCP - SCCM Consensus Conference, Chicago 1992)

Cause

An MOV can be the result of a variety of pathological changes of the body. It often occurs in sepsis, multiple trauma patients or in decompensated internal medicine diseases such as heart failure or due to a marked allergic reaction ( anaphylactic shock ) to a MOV.

It may be affected following organ systems:

  • Lung: ARDS
  • Cardiovascular system: acute circulatory insufficiency
  • Kidney: Acute renal failure
  • Liver: Acute liver failure through to liver failure
  • Coagulation system: the platelet count, increased bleeding tendency
  • Gastrointestinal tract: cholecystitis, stress ulcer to colitis and peritonitis

Treatment

The treatment of the MOV is generally associated with the recording to an intensive care unit, as this is a life-threatening condition. In the ICU, there are methods to supplement or replace entirely (eg, mechanical ventilation, dialysis, circulatory support by drugs, etc.), the function of failed organs, yet a MOV is still associated with a very high mortality rate.

Biological system Polytrauma Acute kidney injury Intensive care medicine
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