Multiplicity of Infection

With Multiplicity of infection (MOI, multiplicity of infection dt ) the numerical ratio of infectious agents ( virus particles or phage ) is described on their target cells in virology. When cells are infected in cell culture with virus particles then can the MOI of that culture calculated by the number of viruses is divided by the number of cells. At an MOI of 1 as many virus particles are used exactly how cells are in culture. The probability that a given cell is actually infected subject to statistical Poisson distribution. The MOI is used in research in the transduction, are introduced in the genes by viruses in bacteria or cells that incorporate these genes into their genome and produce the proteins encoded in the sequence.

At an MOI of 1 (1 virus particle per cell) is the probability that a cell is not infected, the probability that it is infected with a single virus particle, particles of two out of three, and so on. Therefrom, the average percentage of cells that are infected with a given MOI, are calculated through.

The average number of cells which are infected at a MOI of specific, can be calculated by:

If the laboratory bacteria or cells infected with viruses, the following formula is applied: