Mupirocin

Pseudomonic A

• R01AX06
• D06AX09

Antibiotic

78-79 ° C

1310 mg · kg -1 ( LD50, rat, i.v.)

Template: Infobox chemical / molecular formula search available

Mupirocin is a drug selected from the group of antibiotics, is used for the elimination of staphylococci from the nasal mucosa, and in the topical treatment of skin infections. It was discovered in the bacterium Pseudomonas fluorescens.

• 2.1 Mechanism of action ( pharmacodynamics )
• 2.2 Absorption and distribution in the body ( pharmacokinetics )

Clinical information

Areas of application (indications )

Mupirocin is used to eliminate inter alia, certain multidrug-resistant staphylococci in the nasopharynx. V.A. and Streptococcal Infections with Streptococcus pyogenes are so treatable. There is also a preparation for topical treatment of skin infections such as impetigo, Folliculitis ( folliculitis ) or infected eczema and boils or carbuncles additional treatment for. Infections with gram -negative bacteria, anaerobes and Enterococcus species can not be treated with mupirocin.

Posology and method of administration

For use in the nose a matchstick head-sized amount is introduced into the nose and distributed within two to three times daily. In case of skin infection, the ointment should be applied thinly with the drug one to three times daily to the affected areas. It is recommended a treatment period of 5-7 days.

Contraindications ( contraindications)

The ointments should not be applied to the conjunctiva of the eyes. The dosage form for the treatment of skin infections in addition, shall not be applied to the nasal mucosa. The treatment of nasal ointment must not be in infants, as they could absorb the ointment into the airways.

Pregnancy & Lactation

There are no data on use during pregnancy or lactation and it is also not known whether mupirocin passes into breast milk. Therefore, the indication must be particularly strictly made ​​here.

Adverse effects (side effects)

For the nose use may occasionally result in incompatibility reactions in the nasal mucosa and rarely hypersensitivity reactions on the skin. The skin ointment often leads to burning, sometimes itching, stinging, redness and dryness of the treated areas. Very rare systemic allergic reactions have been reported. Prolonged use can lead to the colonization of bacteria that are resistant to the drug.

Pharmacological properties

Mechanism of action ( pharmacodynamics )

As a metabolite of the bacterial strain Pseudomonas fluorescens mupirocin acts by a bacterial enzyme RNA synthetase ( isoleucyl -tRNA synthetase ) inhibits. In this way the bacterial protein synthesis is inhibited ( inhibited ). In higher concentrations, it is bactericidal thereby. At concentrations near the " Minimum Inhibitory Concentration, MIC " the effect is bacteriostatic.

Uptake and distribution in the body ( pharmacokinetics )

Following oral or intravenous administration, mupirocin is rapidly converted to the ineffective Moninsäure and is therefore only suitable for local application. For application to the mucosa in the amount less than 1% is excreted via the kidneys as Moninsäure.

Trade names

Bactroban (A, CH), Infectopyoderm (D), Turixin (D)