In 1993 he founded with Nelly, Ali, City Spud Kyjuan and the St. Lunatics. In 1996 the joint EP Gimme What You Got and the musicians stayed with Universal Records. When Nelly launched his successful solo career, and the other band members were represented at different songs, Murphy Lee, for example, at Batter Up (2001 ) and Air Force Ones ( 2002). Even with songs by Jermaine Dupri, Lil Wayne and the Ying Yang Twins, he entered appearance.
2003 was the season of his big breakthrough. Yet along with Nelly and P. Diddy Shake Ya Tailfeather he had with a number-one hit in the U.S. and the trio got a year later won a Grammy for the song comes from the soundtrack of the film Bad Boys II. In addition, his first solo album was released under the title of Murphy 's Law. The album reached number 8 in the U.S. top 200 and reached platinum status. The first single Wat Da Hook Gon Be came in at number 17 of the U.S. Hot 100 and in the top 10 rap charts. Also the song Luv Me Baby was still quite successful.
With UC -ME Entertainment Murphy Lee founded his own record label. He is also the owner of two snack bars in St. Louis with the name Good For You Cafe.
For 2008, a sequel is his musical career with the new album You See Me