Myelin basic protein

  • OMIM: 159430
  • UniProt: P02686
  • MGI: 96925

The Myelin Basic Protein ( MBP, Eng. Myelin basic protein ) is a protein that has an important role for the myelin sheath of nerve cells. The protein content of myelin, it makes up about 40 percent. In the research on the origins of multiple sclerosis ( MS), the animal model " experimental autoimmune encephalomyelitis " (EAE ), it is next to the myelin oligodendrocyte glycoprotein ( MOG) an autoantigen frequently used. The gene that encodes MBP, located in humans on chromosome 18 in the region that is affected in trisomy 18. After it was first isolated from the myelin sheath, its amino acid composition was determined in 1979.

Dirucotid (MBP8298), a synthetic fragment of the MBP consisting of the 17 amino acids of the position 82-98 of MBP could be delayed with progressive MS, the progression of the disease in different patients.

BHT -3009 and atorvastatin should both reduce the body's immune response to MBP.

A proof of MBP in the CSF of more than 9 ng / mL suggests an acute myelin damage; Values ​​between 4 and 8 ng / ml to a chronic injury or a recovery phase after an acute injury. As an acute injury are here

  • An active process in the context of a demyelinating disease including multiple sclerosis
  • Various encephalopathies
  • Stroke
  • Bleeding in the central nervous system
  • Acute craniocerebral trauma

With the knowledge that prions not only trigger a bovine spongiform encephalopathy in cattle, but can present a risk for humans, the need for bovine brain in meat products was demonstrated. This is possible with an indirect ELISA based on the detection of MBP.

Protein isoform Human Genome Organisation Mouse Genome Informatics Pathogenesis Dirucotide Digital Object Identifier
589220
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