Myoblast

A myoblast (from Greek μῦς, mys " muscle ", βλάστος, blastos " germ "), even Sarko Blast (Greek σάρξ, sarx "flesh" ), is a spindle-shaped precursor cells of skeletal muscle fibers in the embryo. Myoblasts develop from Prämyoblasten in the myotome and they come from the middle germ layer (mesoderm ).

Myoblasts synthesize the myofilaments actin and myosin. In contrast to the later a muscle myoblast cell has only one core. Through cell fusion arise from myoblasts via the intermediate stage of multicellular myotubes the definitive muscle cells ( fibers ).

After birth, the thickening of the muscle takes place, for example through training, mainly by thickening (hypertrophy ) of existing, but not by proliferation ( hyperplasia) of muscle fibers. In the limited amount of regeneration of muscle fibers by myoblasts is possible in adults. The after birth seated under the basement membrane of skeletal muscle myoblasts are called satellite cells. This may cause the incorporation of thymidine into actively dividing radiärem muscle regeneration of muscles after muscle fiber tears. In most cases, a muscle injury but scarred connective tissue.

Clinical aspects

The transplantation of myoblasts into dead heart muscle after a heart attack areas is currently the subject of intense scientific investigation.

Also in the research is the growing of in vitro meat from myoblasts.

Benign tumors of striated muscle is called because of the myoblast -like cells as Myoblastenmyom.

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